Journal of Indian Society of Pedodontics and Preventive Dentistry
Journal of Indian Society of Pedodontics and Preventive Dentistry
                                                   Official journal of the Indian Society of Pedodontics and Preventive Dentistry                           
Year : 2020  |  Volume : 38  |  Issue : 1  |  Page : 8--13

Single-nucleotide polymorphism in Vitamin D receptor gene and its association with dental caries in children


Victoria Guru Aribam1, Nalini Aswath1, Arvind Ramanathan2 
1 Department of Oral Medicine and Radiology, Sree Balaji Dental College and Hospital, BIHER University, Chennai, Tamil Nadu, India
2 Department of Human Genetics Research Laboratory, Sree Balaji Dental College and Hospital, BIHER University, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Nalini Aswath
Department of Oral Medicine and Radiology, Sree Balaji Dental College and Hospital, BIHER University, Chennai - 600 042, Tamil Nadu
India

Background: Though factors such as diet, oral hygiene, salivary flow and surface characteristics of the tooth enamel play a role in the causation of dental caries, genetic factors also contribute significantly in influencing the susceptibility or resistanance to the occurrence of caries. Aims and Objectives: To analyse the relationship between a single nucleotide polymorphism in the vitamin D receptor gene TaqI locus and associate its presence with dental caries in children. Materials and Methods: A case control study was conducted among 120 children in the age group of 6-12 years. 60 cases with a DMFT of >3 and 60 controls with a DMFT of 0 were selected. Genomic DNA was extracted from salivary samples collected from the patients and presence of polymorphism was analyzed by PCR-RFLP. Results: Pearson chi square test and Fisher exact tests were used for comparison of differences in genotypes or allele frequencies between groups. No significant difference between the cases and control was observed among the different genotypes and the alleles. However, there was an inclination in the incidence of caries with the genotype 'tt' and 'Tt' when compared with the genotype'TT'. Conclusion: In this study done to analyse the SNP in vitamin D receptor gene and its association with dental caries in children indicates a higher caries risk for a patient with't' allele and 'tt' genotype.


How to cite this article:
Aribam VG, Aswath N, Ramanathan A. Single-nucleotide polymorphism in Vitamin D receptor gene and its association with dental caries in children.J Indian Soc Pedod Prev Dent 2020;38:8-13


How to cite this URL:
Aribam VG, Aswath N, Ramanathan A. Single-nucleotide polymorphism in Vitamin D receptor gene and its association with dental caries in children. J Indian Soc Pedod Prev Dent [serial online] 2020 [cited 2020 Apr 6 ];38:8-13
Available from: http://www.jisppd.com/article.asp?issn=0970-4388;year=2020;volume=38;issue=1;spage=8;epage=13;aulast=Aribam;type=0