Home | About Us | Editorial Board | Current Issue | Archives | Search | Instructions | Subscription | Feedback | e-Alerts | Login 
Journal of Indian Society of Pedodontics and Preventive Dentistry Official publication of Indian Society of Pedodontics and Preventive Dentistry
 Users Online: 201  
  Print this page Email this page   Small font sizeDefault font sizeIncrease font size
Year : 2017  |  Volume : 35  |  Issue : 2  |  Page : 174-180

Comparison of efficacy of three chemotherapeutic agents on Streptococcus mutans count in plaque and saliva: A randomized controlled triple blind study

1 Department of Pedodontics, Al Azhar Dental College Thodupuzha, Idukki, Kerala, India
2 Department of Pedodontics, K.V.G Dental College and Hospital, Sullia, Karnataka, India
3 Department of Pedodontics, PMS College of Dental Science and Research, Trivandrum, Kerala, India
4 Department of Public Health Dentistry, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India
5 Department of Pedodontics, Dr. D. Y. Patil Dental College and Hospital, Pune, Maharashtra, India
6 Department of Pedodontics, Pacific Dental College and Hospital, Udaipur, Rajasthan, India

Correspondence Address:
Ajay Narayan
Department of Pedodontics, Al-Azhar Dental College Thodupuzha, Idukki, Kerala
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JISPPD.JISPPD_319_16

Rights and Permissions

Background: There is a need for exploration of the role of chemotherapeutic agents and its role in the prevention of early childhood caries (ECC) and its recurrence. Aim: The aim of this study was two-fold: (1) To compare the antimicrobial efficacy of three commonly used chemotherapeutic agents in the prevention of ECC in comparison with a control and (2) To ascertain the role of chemotherapeutic agents in the prevention of ECC. Materials and Methods: Sixty children with ECC in the age group 3–6 years were randomly allocated into four groups. To each group of children after full oral rehabilitation either 10% povidone-iodine (PI), or chlorhexidine (CHX) varnish (Cervitec Plus), or fluoride varnish (Fluor Protector) were applied twice at an interval of 1 week, Group 4 served as control. Streptococcus mutans count in saliva and plaque were collected at baseline, 30, 60, and 90 days and the presence of S. mutans was evaluated using the Dentocult SM strip mutans kit. The efficacy of 10% PI, CHX varnish (Cervitec Plus), and fluoride varnish (Fluor Protector) was compared with the control group at 30, 60, and 90 days. An intergroup comparison was also done during the same time intervals. Results: The reduction of S. mutans count in the plaque and saliva was greatest in the fluoride varnish treated groups at all time intervals (30, 60, and 90 days). Fluoride varnish, CHX varnish, and 10% PI showed significant improved efficacy when compared to the control group (P < 0.001). Fluoride varnish showed significantly lower counts of S. mutans compared to CHX varnish at all time intervals (30, 60, and 90 days) and also significantly lower counts compared to 10% PI at 60 and 90 days interval (P < 0.001).


Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded308    
    Comments [Add]    

Recommend this journal


Contact us | Sitemap | Advertise | What's New | Copyright and Disclaimer 
  2005 - Journal of Indian Society of Pedodontics and Preventive Dentistry | Published by Wolters Kluwer - Medknow 
Online since 1st May '05